ADWFC-12P Reciprocating Cylinder Method Dissolution Sampling Collection System Technical Specification  

1. System Overview  

- Automated dissolution sampling system for pharmaceutical testing  

- Designed for USP Apparatus 3 (Reciprocating Cylinder) applications  

- Enables precise sample collection at programmed time points  

2. Working Principle  

- Reciprocating vertical motion of cylinder assemblies  

- Programmable dip rate and stroke length  

- Automated sample collection from multiple vessels  

3. Key Features  

- 12-position sampling capacity  

- Touchscreen control interface  

- Independent vessel temperature control  

- Integrated filtration system  

- Compliant with 21 CFR Part 11  

4. Technical Parameters  

- Vessel capacity: 12 x 250mL vessels  

- Temperature range: 25-45°C (±0.2°C)  

- Dip rate: 5-30 dips per minute  

- Stroke length: 50-100mm adjustable  

- Sampling volume: 1-10mL programmable  

5. Standards Compliance  

- USP <711> Dissolution  

- EP 2.9.3 Dissolution Test for Solid Dosage Forms  

- JP 17 Dissolution Test  

6. Operation Process  

1) System Preparation  

- Fill vessels with dissolution medium  

- Load dosage forms into cylinders  

- Prime sampling lines  

2) Test Programming  

- Set temperature parameters  

- Program dip rate and stroke length  

- Schedule sample collection times  

3) Sample Collection  

- Automated medium withdrawal  

- Integrated filtration  

- Precise volume collection  

7. Performance Metrics  

- Temperature uniformity: ±0.3°C  

- Sampling time accuracy: ±5 seconds  

- Volume accuracy: ±2% of set volume  

8. Applications  

- Extended-release formulation testing  

- Poorly soluble compound evaluation  

- Food-effect simulation studies  

- Quality control testing  

9. Maintenance Requirements  

Daily:  

- Cleaning of vessels and cylinders  

- Verification of temperature calibration  

Weekly:  

- Filter replacement  

- Pump maintenance  

Monthly:  

- Full system calibration  

- Mechanical inspection  

10. Safety Features  

- Over-temperature protection  

- Liquid level sensors  

- Emergency stop function  

- Leak detection  

11. System Advantages  

- Reduced operator intervention  

- Improved reproducibility  

- Flexible study designs  

- Comprehensive data tracking  

12. Customization Options  

- Additional vessel configurations  

- Specialized cylinder designs  

- Dissolution-perfusion capabilities  

- Advanced data analysis packages